| 13. Round | 20/10/2021 | Reading FC | - | Blackpool FC | 2:3 |  |
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| 17. Round | 06/11/2021 | Blackpool FC | - | Queens Park Rangers | 1:1 | ||||
| 18. Round | 20/11/2021 | Swansea City | - | Blackpool FC | 1:1 | ||||
| 19. Round | 23/11/2021 | Blackpool FC | - | West Bromwich Albion | 0:0 | ||||
| 20. Round | 27/11/2021 | Birmingham City | - | Blackpool FC | 1:0 | ||||
| 21. Round | 04/12/2021 | Blackpool FC | - | Luton Town | 0:3 | ||||
| 22. Round | 11/12/2021 | Derby County | - | Blackpool FC | 1:0 | ||||
| 28. Round | 22/01/2022 | Blackpool FC | - | Millwall FC | 1:0 | ||||
| 30. Round | 05/02/2022 | Blackpool FC | - | Bristol City | 3:1 | ||||
| 31. Round | 08/02/2022 | Coventry City | - | Blackpool FC | 1:1 | ||||
| 34. Round | 23/02/2022 | Queens Park Rangers | - | Blackpool FC | 2:1 | ||||
| 37. Round | 12/03/2022 | Blackpool FC | - | Swansea City | 1:0 | ||||
| 42. Round | 15/04/2022 | West Bromwich Albion | - | Blackpool FC | 2:1 | ||||
| 27. Round | 26/04/2022 | Barnsley FC | - | Blackpool FC | 0:2 | |
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| 46. Round | 07/05/2022 | Peterborough United | - | Blackpool FC | 5:0 |
England