| 1. Round | 16/08/2021 | West Bromwich Albion U23 | - | Burnley FC U23 | 3:2 |  |
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| 2. Round | 20/08/2021 | Fulham FC U23 | - | West Bromwich Albion U23 | 3:0 | ||||
| 3. Round | 27/08/2021 | West Bromwich Albion U23 | - | Birmingham City U23 | 3:2 | |
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| 4. Round | 13/09/2021 | West Bromwich Albion U23 | - | Newcastle United U23 | 2:0 | ||||
| 5. Round | 17/09/2021 | Aston Villa U23 | - | West Bromwich Albion U23 | 4:2 | ||||
| 6. Round | 27/09/2021 | Norwich City U23 | - | West Bromwich Albion U23 | 2:5 |  |
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| 10. Round | 01/11/2021 | Nottingham Forest U23 | - | West Bromwich Albion U23 | 2:2 | ||||
| 11. Round | 05/11/2021 | Wolverhampton Wanderers U23 | - | West Bromwich Albion U23 | 1:1 | ||||
| 13. Round | 28/11/2021 | Southampton FC U23 | - | West Bromwich Albion U23 | 3:1 | ||||
| 14. Round | 06/12/2021 | West Bromwich Albion U23 | - | Middlesbrough FC U23 | 3:2 | ||||
| 15. Round | 20/12/2021 | West Bromwich Albion U23 | - | Fulham FC U23 | 2:4 | ||||
| 17. Round | 17/01/2022 | West Bromwich Albion U23 | - | Aston Villa U23 | 2:1 | ||||
| 18. Round | 24/01/2022 | Birmingham City U23 | - | West Bromwich Albion U23 | 3:2 | |
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England