| 1. Round | 11/09/2020 | Arsenal FC U23 | - | Southampton FC U23 | 1:2 | ||||
| 2. Round | 18/09/2020 | Southampton FC U23 | - | Chelsea FC U23 | 1:4 | ||||
| 3. Round | 26/09/2020 | Southampton FC U23 | - | West Ham United U23 | 2:2 | ||||
| 6. Round | 23/10/2020 | Derby County U23 | - | Southampton FC U23 | 3:1 | ||||
| 9. Round | 21/11/2020 | Liverpool FC U23 | - | Southampton FC U23 | 0:0 | ||||
| 7. Round | 04/12/2020 | Manchester United U23 | - | Southampton FC U23 | 3:1 | ||||
| 17. Round | 07/02/2021 | Southampton FC U23 | - | Tottenham Hotspur U23 | 1:1 | ||||
| 18. Round | 08/03/2021 | Blackburn Rovers U23 | - | Southampton FC U23 | 5:1 | ||||
| 22. Round | 21/03/2021 | Southampton FC U23 | - | Liverpool FC U23 | 1:2 |  |
England
Ghana