| 1. Round | 07/08/2010 | Exeter City | - | Colchester United | 2:2 | ||||
| 3. Round | 21/08/2010 | Exeter City | - | Bristol Rovers | 2:2 | ||||
| 4. Round | 28/08/2010 | Leyton Orient | - | Exeter City | 3:0 | ||||
| 5. Round | 04/09/2010 | Exeter City | - | Charlton Athletic | 1:0 | ||||
| 6. Round | 11/09/2010 | Hartlepool United | - | Exeter City | 2:3 | ||||
| 7. Round | 18/09/2010 | Exeter City | - | Peterborough United | 2:2 | ||||
| 2. Round | 21/09/2010 | Dagenham & Redbridge | - | Exeter City | 1:1 | ||||
| 8. Round | 25/09/2010 | Yeovil Town | - | Exeter City | 1:3 | ||||
| 9. Round | 28/09/2010 | AFC Bournemouth | - | Exeter City | 3:0 | ||||
| 10. Round | 02/10/2010 | Exeter City | - | Rochdale AFC | 1:0 | ||||
| 11. Round | 09/10/2010 | Walsall FC | - | Exeter City | 2:1 | ||||
| 12. Round | 16/10/2010 | Exeter City | - | Carlisle United | 2:1 | ||||
| 13. Round | 23/10/2010 | Milton Keynes Dons | - | Exeter City | 1:0 | ||||
| 14. Round | 30/10/2010 | Exeter City | - | Brentford FC | 2:4 | ||||
| 24. Round | 01/01/2011 | Southampton FC | - | Exeter City | 4:0 | ||||
| 25. Round | 03/01/2011 | Exeter City | - | Brighton & Hove Albion | 1:2 | ||||
| 26. Round | 08/01/2011 | Exeter City | - | Milton Keynes Dons | 1:1 | ||||
| 27. Round | 14/01/2011 | Brentford FC | - | Exeter City | 1:1 |
England