| 4. Round | 14/08/2022 | SV Zulte Waregem | - | KRC Genk | 1:4 | ||||
| 5. Round | 20/08/2022 | KRC Genk | - | Cercle Brugge | 2:1 |  |
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| 6. Round | 27/08/2022 | RFC Seraing | - | KRC Genk | 0:4 | ||||
| 7. Round | 03/09/2022 | KRC Genk | - | Sint-Truidense VV | 0:0 | ||||
| 8. Round | 11/09/2022 | Union Saint-Gilloise | - | KRC Genk | 1:2 | |
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| 9. Round | 18/09/2022 | KRC Genk | - | KAA Gent | 1:0 | ||||
| 10. Round | 01/10/2022 | KV Oostende | - | KRC Genk | 1:2 |  |
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| 11. Round | 08/10/2022 | KRC Genk | - | KV Kortrijk | 2:1 | |
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| 12. Round | 15/10/2022 | Oud-Heverlee Leuven | - | KRC Genk | 0:1 | |
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| 13. Round | 18/10/2022 | KRC Genk | - | KVC Westerlo | 6:1 | |
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| 14. Round | 23/10/2022 | Royal Antwerp FC | - | KRC Genk | 1:3 | |
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| 15. Round | 28/10/2022 | KRC Genk | - | KV Mechelen | 3:1 | ||||
| 16. Round | 04/11/2022 | KRC Genk | - | Sporting Charleroi | 4:1 | |
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| 17. Round | 13/11/2022 | RSC Anderlecht | - | KRC Genk | 0:2 | |
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| 18. Round | 26/12/2022 | KV Kortrijk | - | KRC Genk | 1:0 | |
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| 19. Round | 08/01/2023 | KRC Genk | - | Club Brugge KV | 3:1 | |
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| 20. Round | 14/01/2023 | KRC Genk | - | SV Zulte Waregem | 1:0 | ||||
| 21. Round | 17/01/2023 | KVC Westerlo | - | KRC Genk | 2:3 | ||||
| 23. Round | 29/01/2023 | KRC Genk | - | RFC Seraing | 4:0 | |
Nigeria