| 26. Round | 20/02/2022 | Wolverhampton Wanderers | - | Leicester City | 2:1 | ||||
| 20. Round | 24/02/2022 | Arsenal FC | - | Wolverhampton Wanderers | 2:1 | ||||
| 27. Round | 27/02/2022 | West Ham United | - | Wolverhampton Wanderers | 1:0 | ||||
| 28. Round | 05/03/2022 | Wolverhampton Wanderers | - | Crystal Palace | 0:2 | ||||
| 19. Round | 10/03/2022 | Wolverhampton Wanderers | - | Watford FC | 4:0 | ||||
| 31. Round | 02/04/2022 | Wolverhampton Wanderers | - | Aston Villa | 2:1 |  |
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| 32. Round | 08/04/2022 | Newcastle United | - | Wolverhampton Wanderers | 1:0 | ||||
| 34. Round | 24/04/2022 | Burnley FC | - | Wolverhampton Wanderers | 1:0 | |
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| 35. Round | 30/04/2022 | Wolverhampton Wanderers | - | Brighton & Hove Albion | 0:3 | ||||
| 36. Round | 07/05/2022 | Chelsea FC | - | Wolverhampton Wanderers | 2:2 | |
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| 33. Round | 11/05/2022 | Wolverhampton Wanderers | - | Manchester City | 1:5 | ||||
| 37. Round | 15/05/2022 | Wolverhampton Wanderers | - | Norwich City | 1:1 | ||||
| 38. Round | 22/05/2022 | Liverpool FC | - | Wolverhampton Wanderers | 3:1 |  |
Portugal
