| 16. Round | 11/02/2025 | Leyton Orient | - | Mansfield Town | 3:0 | ||||
| 32. Round | 15/02/2025 | Leyton Orient | - | Lincoln City | 3:2 | ||||
| 31. Round | 18/02/2025 | Wrexham AFC | - | Leyton Orient | 1:2 | ||||
| 33. Round | 22/02/2025 | Bolton Wanderers | - | Leyton Orient | 2:1 | ||||
| 26. Round | 25/02/2025 | Birmingham City | - | Leyton Orient | 2:0 | ||||
| 34. Round | 01/03/2025 | Leyton Orient | - | Charlton Athletic | 1:2 | ||||
| 35. Round | 04/03/2025 | Rotherham United | - | Leyton Orient | 1:0 | ||||
| 36. Round | 08/03/2025 | Leyton Orient | - | Northampton Town | 1:2 | ||||
| 37. Round | 15/03/2025 | Blackpool FC | - | Leyton Orient | 1:2 | ||||
| 39. Round | 27/03/2025 | Leyton Orient | - | Stevenage FC | 1:0 | ||||
| 40. Round | 01/04/2025 | Burton Albion | - | Leyton Orient | 2:1 | ||||
| 38. Round | 08/04/2025 | Mansfield Town | - | Leyton Orient | 2:3 | ||||
| 42. Round | 12/04/2025 | Crawley Town | - | Leyton Orient | 1:3 | ||||
| 43. Round | 18/04/2025 | Leyton Orient | - | Barnsley FC | 4:3 | ||||
| 44. Round | 21/04/2025 | Cambridge United | - | Leyton Orient | 1:2 | ||||
| 45. Round | 26/04/2025 | Leyton Orient | - | Wycombe Wanderers | 1:0 | ||||
| 46. Round | 03/05/2025 | Huddersfield Town | - | Leyton Orient | 1:4 |  |
England