| 1. Round | 07/08/2021 | Bristol City | - | Blackpool FC | 1:1 | ||||
| 3. Round | 17/08/2021 | Blackpool FC | - | Coventry City | 0:1 | ||||
| 4. Round | 21/08/2021 | AFC Bournemouth | - | Blackpool FC | 2:2 | ||||
| 5. Round | 28/08/2021 | Millwall FC | - | Blackpool FC | 2:1 | ||||
| 17. Round | 06/11/2021 | Blackpool FC | - | Queens Park Rangers | 1:1 | ||||
| 18. Round | 20/11/2021 | Swansea City | - | Blackpool FC | 1:1 | ||||
| 19. Round | 23/11/2021 | Blackpool FC | - | West Bromwich Albion | 0:0 | ||||
| 20. Round | 27/11/2021 | Birmingham City | - | Blackpool FC | 1:0 | ||||
| 21. Round | 04/12/2021 | Blackpool FC | - | Luton Town | 0:3 | ||||
| 22. Round | 11/12/2021 | Derby County | - | Blackpool FC | 1:0 | ||||
| 23. Round | 18/12/2021 | Blackpool FC | - | Peterborough United | 3:1 | ||||
| 31. Round | 08/02/2022 | Coventry City | - | Blackpool FC | 1:1 |  |
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| 33. Round | 19/02/2022 | Cardiff City | - | Blackpool FC | 1:1 | ||||
| 34. Round | 23/02/2022 | Queens Park Rangers | - | Blackpool FC | 2:1 | |
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| 35. Round | 26/02/2022 | Blackpool FC | - | Reading FC | 4:1 | ||||
| 36. Round | 05/03/2022 | Stoke City | - | Blackpool FC | 0:1 | |
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| 37. Round | 12/03/2022 | Blackpool FC | - | Swansea City | 1:0 |
England
