| 2. Round | 11/08/2018 | Oxford United | - | Fleetwood Town | 0:2 | ||||
| 5. Round | 25/08/2018 | Oxford United | - | Burton Albion | 3:1 |  |
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| 6. Round | 01/09/2018 | Sunderland AFC | - | Oxford United | 1:1 | |
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| 7. Round | 09/09/2018 | Oxford United | - | Coventry City | 1:2 |  |
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| 8. Round | 15/09/2018 | Wycombe Wanderers | - | Oxford United | 0:0 | ||||
| 9. Round | 22/09/2018 | Oxford United | - | Walsall FC | 1:2 | ||||
| 10. Round | 29/09/2018 | AFC Wimbledon | - | Oxford United | 2:1 | ||||
| 11. Round | 02/10/2018 | Oxford United | - | Luton Town | 1:2 | |
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| 12. Round | 06/10/2018 | Southend United | - | Oxford United | 0:0 | ||||
| 13. Round | 13/10/2018 | Oxford United | - | Plymouth Argyle | 2:0 | ||||
| 15. Round | 23/10/2018 | Charlton Athletic | - | Oxford United | 1:1 | ||||
| 16. Round | 27/10/2018 | Oxford United | - | Shrewsbury Town | 3:0 | ||||
| 17. Round | 03/11/2018 | Scunthorpe United | - | Oxford United | 3:3 | ||||
| 18. Round | 17/11/2018 | Oxford United | - | Gillingham FC | 1:0 | ||||
| 21. Round | 08/12/2018 | Peterborough United | - | Oxford United | 2:2 | ||||
| 22. Round | 15/12/2018 | Oxford United | - | Blackpool FC | 2:0 |
England