| 1. Round | 12/09/2020 | Northampton Town | - | AFC Wimbledon | 2:2 |  |
|||
| 4. Round | 03/10/2020 | Bristol Rovers | - | Northampton Town | 2:0 | ||||
| 5. Round | 10/10/2020 | Northampton Town | - | Peterborough United | 0:2 |  |
|||
| 6. Round | 17/10/2020 | Plymouth Argyle | - | Northampton Town | 2:1 | |
|||
| 7. Round | 20/10/2020 | Northampton Town | - | Swindon Town | 2:1 | ||||
| 8. Round | 24/10/2020 | Northampton Town | - | Charlton Athletic | 0:2 | ||||
| 9. Round | 27/10/2020 | Portsmouth FC | - | Northampton Town | 4:0 | ||||
| 19. Round | 19/12/2020 | Northampton Town | - | Lincoln City | 0:4 | ||||
| 25. Round | 23/01/2021 | Lincoln City | - | Northampton Town | 2:1 | ||||
| 26. Round | 26/01/2021 | Fleetwood Town | - | Northampton Town | 0:0 | ||||
| 23. Round | 02/02/2021 | Blackpool FC | - | Northampton Town | 2:0 | ||||
| 28. Round | 06/02/2021 | Accrington Stanley | - | Northampton Town | 0:0 | ||||
| 27. Round | 09/02/2021 | Northampton Town | - | Wigan Athletic | 0:1 | ||||
| 33. Round | 02/03/2021 | Northampton Town | - | Plymouth Argyle | 2:0 | ||||
| 24. Round | 23/03/2021 | Northampton Town | - | Oxford United | 1:0 | ||||
| 42. Round | 16/04/2021 | Peterborough United | - | Northampton Town | 3:1 |
England