| 1. Round | 07/08/2021 | Forest Green Rovers | - | Sutton United | 2:1 | ||||
| 4. Round | 21/08/2021 | Scunthorpe United | - | Sutton United | 1:1 | ||||
| 5. Round | 28/08/2021 | Sutton United | - | Oldham Athletic | 1:2 | ||||
| 11. Round | 09/10/2021 | Sutton United | - | Port Vale FC | 4:3 | ||||
| 18. Round | 23/11/2021 | Sutton United | - | Mansfield Town | 2:0 | ||||
| 21. Round | 11/12/2021 | Bradford City | - | Sutton United | 2:2 | ||||
| 24. Round | 18/01/2022 | Sutton United | - | Colchester United | 3:2 | ||||
| 29. Round | 29/01/2022 | Carlisle United | - | Sutton United | 0:2 | ||||
| 23. Round | 15/02/2022 | Bristol Rovers | - | Sutton United | 2:0 | ||||
| 34. Round | 26/02/2022 | Sutton United | - | Scunthorpe United | 4:1 | ||||
| 35. Round | 05/03/2022 | Sutton United | - | Rochdale AFC | 3:0 | ||||
| 36. Round | 12/03/2022 | Walsall FC | - | Sutton United | 1:0 | ||||
| 38. Round | 19/03/2022 | Sutton United | - | Tranmere Rovers | 1:1 | ||||
| 26. Round | 22/03/2022 | Oldham Athletic | - | Sutton United | 1:3 |  |
England