| 17. Round | 12/01/2022 | CD Alavés [Women] | - | Madrid CFF [Women] | 2:1 | ||||
| 18. Round | 15/01/2022 | Madrid CFF [Women] | - | Villarreal CF [Women] | 2:4 | ||||
| 19. Round | 30/01/2022 | SD Eibar [Women] | - | Madrid CFF [Women] | 2:1 | ||||
| 20. Round | 02/02/2022 | Atlético Madrid [Women] | - | Madrid CFF [Women] | 3:2 | ||||
| 21. Round | 06/02/2022 | Madrid CFF [Women] | - | UDG Tenerife Sur [Women] | 0:1 | ||||
| 22. Round | 13/02/2022 | Rayo Vallecano [Women] | - | Madrid CFF [Women] | 3:2 | ||||
| 24. Round | 12/03/2022 | Athletic Club [Women] | - | Madrid CFF [Women] | 2:1 | ||||
| 25. Round | 26/03/2022 | Madrid CFF [Women] | - | FC Barcelona [Women] | 1:2 | ||||
| 26. Round | 02/04/2022 | Real Sociedad [Women] | - | Madrid CFF [Women] | 0:1 |  |
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| 27. Round | 17/04/2022 | Madrid CFF [Women] | - | Real Betis [Women] | 2:2 |  |
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| 28. Round | 01/05/2022 | Real Madrid [Women] | - | Madrid CFF [Women] | 1:0 | ||||
| 30. Round | 15/05/2022 | Sporting de Huelva [Women] | - | Madrid CFF [Women] | 2:0 |
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