| 2. Round | 22/08/2021 | Arsenal FC | - | Chelsea FC | 0:2 |  |
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| 3. Round | 28/08/2021 | Manchester City | - | Arsenal FC | 5:0 | ||||
| 16. Round | 11/12/2021 | Arsenal FC | - | Southampton FC | 3:0 | ||||
| 19. Round | 26/12/2021 | Norwich City | - | Arsenal FC | 0:5 | ||||
| 21. Round | 01/01/2022 | Arsenal FC | - | Manchester City | 1:2 | |
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| 23. Round | 23/01/2022 | Arsenal FC | - | Burnley FC | 0:0 | ||||
| 24. Round | 10/02/2022 | Wolverhampton Wanderers | - | Arsenal FC | 0:1 | ||||
| 28. Round | 06/03/2022 | Watford FC | - | Arsenal FC | 2:3 | ||||
| 30. Round | 19/03/2022 | Aston Villa | - | Arsenal FC | 0:1 | ||||
| 25. Round | 20/04/2022 | Chelsea FC | - | Arsenal FC | 2:4 | ||||
| 34. Round | 23/04/2022 | Arsenal FC | - | Manchester United | 3:1 | ||||
| 35. Round | 01/05/2022 | West Ham United | - | Arsenal FC | 1:2 |  |
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| 36. Round | 08/05/2022 | Arsenal FC | - | Leeds United | 2:1 | ||||
| 22. Round | 12/05/2022 | Tottenham Hotspur | - | Arsenal FC | 3:0 |  |
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| 38. Round | 22/05/2022 | Arsenal FC | - | Everton FC | 5:1 |
England
