| 1. Round | 21/08/1965 | Everton FC | - | Northampton Town | 5:2 |  |
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| 2. Round | 25/08/1965 | Northampton Town | - | Arsenal FC | 1:1 | ||||
| 3. Round | 28/08/1965 | Northampton Town | - | Manchester United | 1:1 | |
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| 5. Round | 04/09/1965 | Newcastle United | - | Northampton Town | 2:0 | ||||
| 6. Round | 07/09/1965 | Burnley FC | - | Northampton Town | 4:1 | ||||
| 13. Round | 16/10/1965 | Leeds United | - | Northampton Town | 6:1 | ||||
| 14. Round | 23/10/1965 | Northampton Town | - | West Ham United | 2:1 | ||||
| 15. Round | 30/10/1965 | Sunderland AFC | - | Northampton Town | 3:0 | ||||
| 16. Round | 06/11/1965 | Northampton Town | - | Aston Villa | 2:1 | ||||
| 17. Round | 13/11/1965 | Liverpool FC | - | Northampton Town | 5:0 | ||||
| 19. Round | 27/11/1965 | Fulham FC | - | Northampton Town | 1:4 | |
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| 20. Round | 04/12/1965 | Northampton Town | - | Blackpool FC | 2:1 | ||||
| 21. Round | 11/12/1965 | Blackburn Rovers | - | Northampton Town | 6:1 |
England