| 1. Round | 07/08/2010 | Reading FC | - | Scunthorpe United | 1:2 |  |
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| 2. Round | 14/08/2010 | Scunthorpe United | - | Norwich City | 0:1 | ||||
| 4. Round | 28/08/2010 | Scunthorpe United | - | Crystal Palace | 3:0 | ||||
| 5. Round | 11/09/2010 | Scunthorpe United | - | Bristol City | 0:2 | ||||
| 7. Round | 18/09/2010 | Swansea City | - | Scunthorpe United | 2:0 | ||||
| 8. Round | 25/09/2010 | Scunthorpe United | - | Ipswich Town | 1:1 | ||||
| 9. Round | 28/09/2010 | Scunthorpe United | - | Barnsley FC | 0:0 | ||||
| 11. Round | 16/10/2010 | Scunthorpe United | - | Doncaster Rovers | 1:3 |  |
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| 12. Round | 19/10/2010 | Preston North End | - | Scunthorpe United | 2:3 | ||||
| 17. Round | 13/11/2010 | Scunthorpe United | - | Cardiff City | 2:4 | ||||
| 18. Round | 20/11/2010 | Derby County | - | Scunthorpe United | 3:2 | ||||
| 19. Round | 27/11/2010 | Scunthorpe United | - | Coventry City | 0:2 | ||||
| 20. Round | 04/12/2010 | Millwall FC | - | Scunthorpe United | 3:0 | |
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| 24. Round | 28/12/2010 | Burnley FC | - | Scunthorpe United | 0:2 |
England