| 1. Round | 08/10/2020 | Uruguay | - | Chile | 2:1 |  |
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| 2. Round | 13/10/2020 | Ecuador | - | Uruguay | 4:2 | ||||
| 3. Round | 13/11/2020 | Colombia | - | Uruguay | 0:3 | ||||
| 4. Round | 17/11/2020 | Uruguay | - | Brazil | 0:2 | ||||
| 7. Round | 03/06/2021 | Uruguay | - | Paraguay | 0:0 | |
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| 9. Round | 03/09/2021 | Peru | - | Uruguay | 1:1 | ||||
| 6. Round | 05/09/2021 | Uruguay | - | Bolivia | 4:2 | ||||
| 10. Round | 09/09/2021 | Uruguay | - | Ecuador | 1:0 | |
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| 11. Round | 08/10/2021 | Uruguay | - | Colombia | 0:0 | |
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| 12. Round | 15/10/2021 | Brazil | - | Uruguay | 4:1 | ||||
| 13. Round | 12/11/2021 | Uruguay | - | Argentina | 0:1 | ||||
| 14. Round | 16/11/2021 | Bolivia | - | Uruguay | 3:0 | ||||
| 15. Round | 27/01/2022 | Paraguay | - | Uruguay | 0:1 | |
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| 16. Round | 01/02/2022 | Uruguay | - | Venezuela | 4:1 |  |
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| 17. Round | 24/03/2022 | Uruguay | - | Peru | 1:0 | ||||
| 18. Round | 30/03/2022 | Chile | - | Uruguay | 0:2 | |
Uruguay
