| 1. Round | 15/08/2021 | Southampton FC U23 | - | Norwich City U23 | 0:3 | ||||
| 2. Round | 23/08/2021 | Nottingham Forest U23 | - | Southampton FC U23 | 0:0 |  |
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| 3. Round | 29/08/2021 | Middlesbrough FC U23 | - | Southampton FC U23 | 2:1 | ||||
| 9. Round | 25/10/2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | |
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| 24. Round | 02/04/2022 | Burnley FC U23 | - | Southampton FC U23 | 2:1 | |
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| 25. Round | 25/04/2022 | Newcastle United U23 | - | Southampton FC U23 | 2:4 | ||||
| 26. Round | 01/05/2022 | Southampton FC U23 | - | Sunderland AFC U23 | 1:0 |
England