| 12. Round | 21/11/2021 | Tottenham Hotspur | - | Leeds United | 2:1 | ||||
| 15. Round | 05/12/2021 | Tottenham Hotspur | - | Norwich City | 3:0 | ||||
| 18. Round | 19/12/2021 | Tottenham Hotspur | - | Liverpool FC | 2:2 | ||||
| 23. Round | 23/01/2022 | Chelsea FC | - | Tottenham Hotspur | 2:0 | ||||
| 25. Round | 13/02/2022 | Tottenham Hotspur | - | Wolverhampton Wanderers | 0:2 | ||||
| 26. Round | 19/02/2022 | Manchester City | - | Tottenham Hotspur | 2:3 | ||||
| 13. Round | 23/02/2022 | Burnley FC | - | Tottenham Hotspur | 1:0 | ||||
| 27. Round | 26/02/2022 | Leeds United | - | Tottenham Hotspur | 0:4 |  |
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| 28. Round | 07/03/2022 | Tottenham Hotspur | - | Everton FC | 5:0 | ||||
| 34. Round | 23/04/2022 | Brentford FC | - | Tottenham Hotspur | 0:0 | ||||
| 35. Round | 01/05/2022 | Tottenham Hotspur | - | Leicester City | 3:1 | ||||
| 36. Round | 07/05/2022 | Liverpool FC | - | Tottenham Hotspur | 1:1 | |
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| 22. Round | 12/05/2022 | Tottenham Hotspur | - | Arsenal FC | 3:0 | ||||
| 37. Round | 15/05/2022 | Tottenham Hotspur | - | Burnley FC | 1:0 | ||||
| 38. Round | 22/05/2022 | Norwich City | - | Tottenham Hotspur | 0:5 |
England
