| 6. Round | 11/09/2021 | Blackpool FC | - | Fulham FC | 1:0 | ||||
| 7. Round | 14/09/2021 | Blackpool FC | - | Huddersfield Town | 0:3 | ||||
| 8. Round | 18/09/2021 | Middlesbrough FC | - | Blackpool FC | 1:2 | ||||
| 9. Round | 25/09/2021 | Blackpool FC | - | Barnsley FC | 1:0 |  |
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| 10. Round | 28/09/2021 | Hull City | - | Blackpool FC | 1:1 | ||||
| 11. Round | 02/10/2021 | Blackpool FC | - | Blackburn Rovers | 2:1 | |
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| 12. Round | 16/10/2021 | Nottingham Forest | - | Blackpool FC | 2:1 | ||||
| 13. Round | 20/10/2021 | Reading FC | - | Blackpool FC | 2:3 | ||||
| 14. Round | 23/10/2021 | Blackpool FC | - | Preston North End | 2:0 | ||||
| 15. Round | 30/10/2021 | Sheffield United | - | Blackpool FC | 0:1 | ||||
| 16. Round | 03/11/2021 | Blackpool FC | - | Stoke City | 0:1 | ||||
| 17. Round | 06/11/2021 | Blackpool FC | - | Queens Park Rangers | 1:1 | ||||
| 18. Round | 20/11/2021 | Swansea City | - | Blackpool FC | 1:1 | ||||
| 19. Round | 23/11/2021 | Blackpool FC | - | West Bromwich Albion | 0:0 | |
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| 21. Round | 04/12/2021 | Blackpool FC | - | Luton Town | 0:3 | ||||
| 22. Round | 11/12/2021 | Derby County | - | Blackpool FC | 1:0 | ||||
| 23. Round | 18/12/2021 | Blackpool FC | - | Peterborough United | 3:1 | ||||
| 26. Round | 01/01/2022 | Blackpool FC | - | Hull City | 1:0 |
England