| 6. Round | 07/08/2022 | Birmingham Legion | - | Atlanta United II | 6:0 |  |
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| 6. Round | 14/08/2022 | Birmingham Legion | - | San Diego Loyal | 1:0 |  |
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| 6. Round | 18/08/2022 | Birmingham Legion | - | Detroit City FC | 1:2 | ||||
| 6. Round | 21/08/2022 | Memphis 901 | - | Birmingham Legion | 2:4 | ||||
| 6. Round | 28/08/2022 | Birmingham Legion | - | New York RB II | 3:1 | ||||
| 7. Round | 04/09/2022 | Miami FC | - | Birmingham Legion | 1:1 | ||||
| 7. Round | 11/09/2022 | Indy Eleven | - | Birmingham Legion | 4:3 | ||||
| 7. Round | 15/09/2022 | Birmingham Legion | - | Pittsburgh Riverhounds | 2:1 | |
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| 7. Round | 24/09/2022 | Tampa Bay Rowdies | - | Birmingham Legion | 1:1 | ||||
| 8. Round | 02/10/2022 | Oakland Roots | - | Birmingham Legion | 2:1 | ||||
| 8. Round | 09/10/2022 | Birmingham Legion | - | San Antonio FC | 1:2 | ||||
| 8. Round | 13/10/2022 | Birmingham Legion | - | Indy Eleven | 3:1 |
England