| 24. Round | 29/01/2022 | Hamilton Academical | - | Ayr United | 1:1 |  |
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| 20. Round | 01/02/2022 | Partick Thistle | - | Ayr United | 1:0 |  |
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| 25. Round | 05/02/2022 | Ayr United | - | Dunfermline Athletic | 1:1 | ||||
| 21. Round | 09/02/2022 | Kilmarnock FC | - | Ayr United | 1:2 | ||||
| 26. Round | 19/02/2022 | Inverness CT | - | Ayr United | 1:2 | ||||
| 27. Round | 26/02/2022 | Ayr United | - | Queen Of The South | 0:1 | ||||
| 28. Round | 05/03/2022 | Raith Rovers | - | Ayr United | 0:4 | |
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| 29. Round | 11/03/2022 | Ayr United | - | Kilmarnock FC | 1:3 | ||||
| 30. Round | 19/03/2022 | Arbroath FC | - | Ayr United | 1:0 |  |
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| 33. Round | 09/04/2022 | Ayr United | - | Inverness CT | 2:2 | ||||
| 34. Round | 16/04/2022 | Dunfermline Athletic | - | Ayr United | 2:1 | ||||
| 35. Round | 23/04/2022 | Queen Of The South | - | Ayr United | 1:1 | ||||
| 36. Round | 29/04/2022 | Ayr United | - | Partick Thistle | 3:1 |
England