| 8. Round | 16/10/2016 | Southampton FC | - | Burnley FC | 3:1 | ||||
| 9. Round | 23/10/2016 | Manchester City | - | Southampton FC | 1:1 | ||||
| 10. Round | 30/10/2016 | Southampton FC | - | Chelsea FC | 0:2 | ||||
| 13. Round | 27/11/2016 | Southampton FC | - | Everton FC | 1:0 | ||||
| 14. Round | 03/12/2016 | Crystal Palace | - | Southampton FC | 3:0 | ||||
| 15. Round | 11/12/2016 | Southampton FC | - | Middlesbrough FC | 1:0 | ||||
| 16. Round | 14/12/2016 | Stoke City | - | Southampton FC | 0:0 | ||||
| 19. Round | 31/12/2016 | Southampton FC | - | West Bromwich Albion | 1:2 | ||||
| 20. Round | 02/01/2017 | Everton FC | - | Southampton FC | 3:0 | ||||
| 23. Round | 31/01/2017 | Swansea City | - | Southampton FC | 2:1 | ||||
| 30. Round | 01/04/2017 | Southampton FC | - | AFC Bournemouth | 0:0 | ||||
| 31. Round | 05/04/2017 | Southampton FC | - | Crystal Palace | 3:1 | ||||
| 32. Round | 08/04/2017 | West Bromwich Albion | - | Southampton FC | 0:1 |
England