| 1. Round | 10/08/2015 | Southampton FC U21 | - | Manchester City U21 | 2:2 | ||||
| 2. Round | 14/08/2015 | Chelsea FC U21 | - | Southampton FC U21 | 1:3 |  |
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| 3. Round | 24/08/2015 | Southampton FC U21 | - | Middlesbrough FC U21 | 1:1 | ||||
| 4. Round | 14/09/2015 | Southampton FC U21 | - | Leicester City U21 | 3:1 | |
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| 5. Round | 21/09/2015 | Reading FC U21 | - | Southampton FC U21 | 2:5 | |
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| 6. Round | 28/09/2015 | Southampton FC U21 | - | Sunderland AFC U21 | 0:2 | ||||
| 10. Round | 07/12/2015 | Tottenham Hotspur U21 | - | Southampton FC U21 | 0:2 | ||||
| 13. Round | 14/12/2015 | Manchester City U21 | - | Southampton FC U21 | 3:1 |
England