| 5. Round | 03/09/2022 | Liverpool FC U21 | - | Manchester United U21 | 2:2 |  |
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| 8. Round | 01/10/2022 | Blackburn Rovers U21 | - | Manchester United U21 | 6:1 | ||||
| 10. Round | 15/10/2022 | Chelsea FC U21 | - | Manchester United U21 | 3:3 | ||||
| 11. Round | 22/10/2022 | Manchester United U21 | - | Wolverhampton Wanderers U21 | 3:2 | |
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| 16. Round | 20/01/2023 | West Ham United U21 | - | Manchester United U21 | 2:3 | ||||
| 17. Round | 27/01/2023 | Manchester United U21 | - | Blackburn Rovers U21 | 2:1 | ||||
| 18. Round | 11/02/2023 | Manchester United U21 | - | Everton FC U21 | 4:1 | ||||
| 20. Round | 24/02/2023 | Wolverhampton Wanderers U21 | - | Manchester United U21 | 2:2 | ||||
| 23. Round | 31/03/2023 | Manchester United U21 | - | Arsenal FC U21 | 1:1 | |
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| 25. Round | 21/04/2023 | Brighton & Hove Albion U21 | - | Manchester United U21 | 3:2 | |
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| 26. Round | 28/04/2023 | Manchester United U21 | - | Tottenham Hotspur U21 | 2:2 | ||||
| 6. Round | 05/05/2023 | Manchester United U21 | - | Leicester City U21 | 2:2 |
England