| 28. Round | 15/01/2022 | Lincoln City | - | Cambridge United | 0:1 | ||||
| 25. Round | 18/01/2022 | Cambridge United | - | Doncaster Rovers | 3:1 | ||||
| 29. Round | 22/01/2022 | Cambridge United | - | Crewe Alexandra | 1:0 |  |
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| 27. Round | 01/02/2022 | Bolton Wanderers | - | Cambridge United | 2:0 | ||||
| 32. Round | 08/02/2022 | Gillingham FC | - | Cambridge United | 1:0 | ||||
| 33. Round | 12/02/2022 | Burton Albion | - | Cambridge United | 2:2 | |
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| 34. Round | 19/02/2022 | Cambridge United | - | Accrington Stanley | 2:0 | ||||
| 35. Round | 22/02/2022 | Cambridge United | - | Plymouth Argyle | 2:0 | ||||
| 36. Round | 26/02/2022 | Oxford United | - | Cambridge United | 4:2 | ||||
| 24. Round | 01/03/2022 | Wycombe Wanderers | - | Cambridge United | 3:0 | ||||
| 38. Round | 12/03/2022 | Sheffield Wednesday | - | Cambridge United | 6:0 | ||||
| 40. Round | 26/03/2022 | AFC Wimbledon | - | Cambridge United | 0:1 | ||||
| 41. Round | 02/04/2022 | Ipswich Town | - | Cambridge United | 0:1 | ||||
| 42. Round | 09/04/2022 | Cambridge United | - | Morecambe FC | 2:1 |
England