| 1. Round | 16/08/2021 | West Bromwich Albion U23 | - | Burnley FC U23 | 3:2 | ||||
| 2. Round | 23/08/2021 | Burnley FC U23 | - | Sunderland AFC U23 | 2:3 | ||||
| 3. Round | 27/08/2021 | Newcastle United U23 | - | Burnley FC U23 | 2:0 | ||||
| 4. Round | 10/09/2021 | Burnley FC U23 | - | Wolverhampton Wanderers U23 | 1:1 | ||||
| 5. Round | 19/09/2021 | Southampton FC U23 | - | Burnley FC U23 | 0:2 |  |
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| 6. Round | 27/09/2021 | Burnley FC U23 | - | Reading FC U23 | 3:1 | |
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| 7. Round | 01/10/2021 | Nottingham Forest U23 | - | Burnley FC U23 | 1:1 | ||||
| 22. Round | 14/03/2022 | Reading FC U23 | - | Burnley FC U23 | 2:1 | ||||
| 19. Round | 08/04/2022 | Burnley FC U23 | - | Newcastle United U23 | 5:1 | ||||
| 20. Round | 22/04/2022 | Stoke City U23 | - | Burnley FC U23 | 0:0 | ||||
| 25. Round | 25/04/2022 | Burnley FC U23 | - | Aston Villa U23 | 2:1 |
England