| 1. Round | 16/05/2021 | Orlando Pride [Women] | - | Washington Spirit [Women] | 1:1 | ||||
| 1. Round | 22/05/2021 | Racing Louisville [Women] | - | Washington Spirit [Women] | 2:0 | ||||
| 4. Round | 08/08/2021 | Washington Spirit [Women] | - | Portland Thorns [Women] | 0:1 | ||||
| 4. Round | 14/08/2021 | Houston Dash [Women] | - | Washington Spirit [Women] | 2:2 | ||||
| 4. Round | 22/08/2021 | Washington Spirit [Women] | - | Orlando Pride [Women] | 2:1 | ||||
| 5. Round | 26/09/2021 | Washington Spirit [Women] | - | Kansas City NWSL [Women] | 2:1 | ||||
| 6. Round | 10/10/2021 | Washington Spirit [Women] | - | Racing Louisville [Women] | 3:0 | ||||
| 6. Round | 17/10/2021 | OL Reign [Women] | - | Washington Spirit [Women] | 0:2 |
Japan