| 15. Round | 23/10/2021 | Burton Albion | - | Oxford United | 1:3 | ||||
| 16. Round | 30/10/2021 | Oxford United | - | Morecambe FC | 3:1 | ||||
| 17. Round | 13/11/2021 | Ipswich Town | - | Oxford United | 0:0 | ||||
| 12. Round | 04/12/2021 | Sunderland AFC | - | Oxford United | 1:1 | ||||
| 21. Round | 07/12/2021 | Doncaster Rovers | - | Oxford United | 1:2 | ||||
| 22. Round | 11/12/2021 | Milton Keynes Dons | - | Oxford United | 1:2 | ||||
| 23. Round | 18/12/2021 | Oxford United | - | Wigan Athletic | 2:3 | ||||
| 25. Round | 29/12/2021 | Oxford United | - | AFC Wimbledon | 3:0 | ||||
| 26. Round | 01/01/2022 | Oxford United | - | Cheltenham Town | 1:1 | ||||
| 27. Round | 08/01/2022 | Lincoln City | - | Oxford United | 2:0 | ||||
| 28. Round | 15/01/2022 | Wycombe Wanderers | - | Oxford United | 2:0 | ||||
| 38. Round | 12/03/2022 | Shrewsbury Town | - | Oxford United | 1:2 | ||||
| 39. Round | 19/03/2022 | Oxford United | - | Ipswich Town | 1:1 | ||||
| 41. Round | 02/04/2022 | Plymouth Argyle | - | Oxford United | 1:0 |
England
