| 3. Round | 15/08/2005 | Port Vale FC | - | Brentford FC | 1:0 | ||||
| 5. Round | 27/08/2005 | Port Vale FC | - | Doncaster Rovers | 2:0 |  |
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| 7. Round | 03/09/2005 | Port Vale FC | - | Rotherham United | 2:0 | ||||
| 8. Round | 10/09/2005 | Scunthorpe United | - | Port Vale FC | 2:0 | ||||
| 9. Round | 17/09/2005 | Port Vale FC | - | Colchester United | 0:1 |  |
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| 10. Round | 24/09/2005 | Yeovil Town | - | Port Vale FC | 1:0 | ||||
| 12. Round | 01/10/2005 | Port Vale FC | - | Walsall FC | 3:2 | ||||
| 15. Round | 22/10/2005 | AFC Bournemouth | - | Port Vale FC | 1:2 | |
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| 16. Round | 29/10/2005 | Port Vale FC | - | Hartlepool United | 1:2 | |
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| 18. Round | 19/11/2005 | Port Vale FC | - | Swindon Town | 1:1 | ||||
| 19. Round | 26/11/2005 | Port Vale FC | - | Southend United | 2:1 | ||||
| 20. Round | 06/12/2005 | Nottingham Forest | - | Port Vale FC | 1:0 | ||||
| 21. Round | 10/12/2005 | Gillingham FC | - | Port Vale FC | 3:0 | ||||
| 22. Round | 17/12/2005 | Port Vale FC | - | Bristol City | 0:1 | ||||
| 24. Round | 28/12/2005 | Huddersfield Town | - | Port Vale FC | 0:3 | |
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| 25. Round | 31/12/2005 | Port Vale FC | - | Tranmere Rovers | 0:2 | ||||
| 26. Round | 02/01/2006 | Swansea City | - | Port Vale FC | 0:0 | |
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| 27. Round | 10/01/2006 | Rotherham United | - | Port Vale FC | 1:1 |
Wales