| 6. Round | 07/11/2021 | Birmingham City WFC [Women] | - | Reading WFC [Women] | 0:3 | ||||
| 8. Round | 21/11/2021 | Reading WFC [Women] | - | Brighton & Hove Albion WFC [Women] | 2:0 | ||||
| 11. Round | 09/01/2022 | Reading WFC [Women] | - | Leicester City WFC [Women] | 1:0 | ||||
| 14. Round | 06/02/2022 | Everton FC [Women] | - | Reading WFC [Women] | 1:2 |  |
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| 15. Round | 13/02/2022 | Brighton & Hove Albion WFC [Women] | - | Reading WFC [Women] | 4:1 | ||||
| 12. Round | 02/03/2022 | Arsenal WFC [Women] | - | Reading WFC [Women] | 4:0 | ||||
| 19. Round | 03/04/2022 | Chelsea FC Women [Women] | - | Reading WFC [Women] | 5:0 | ||||
| 20. Round | 24/04/2022 | Reading WFC [Women] | - | West Ham United WFC [Women] | 1:2 | ||||
| 21. Round | 01/05/2022 | Leicester City WFC [Women] | - | Reading WFC [Women] | 0:0 | ||||
| 22. Round | 08/05/2022 | Reading WFC [Women] | - | Manchester City WFC [Women] | 0:4 | |
England