| 1. Round | 07/08/2021 | Oldham Athletic | - | Newport County | 0:1 |  |
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| 2. Round | 14/08/2021 | Mansfield Town | - | Newport County | 2:1 | |
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| 4. Round | 21/08/2021 | Tranmere Rovers | - | Newport County | 0:1 | ||||
| 5. Round | 28/08/2021 | Salford City | - | Newport County | 3:0 | |
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| 6. Round | 04/09/2021 | Newport County | - | Leyton Orient | 2:2 | ||||
| 7. Round | 10/09/2021 | Harrogate Town | - | Newport County | 2:2 | ||||
| 3. Round | 14/09/2021 | Newport County | - | Northampton Town | 0:1 | ||||
| 9. Round | 24/09/2021 | Barrow AFC | - | Newport County | 2:1 | ||||
| 10. Round | 02/10/2021 | Newport County | - | Scunthorpe United | 3:0 | ||||
| 14. Round | 23/10/2021 | Bristol Rovers | - | Newport County | 1:3 | |
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| 17. Round | 20/11/2021 | Newport County | - | Swindon Town | 1:2 | ||||
| 22. Round | 18/12/2021 | Rochdale AFC | - | Newport County | 3:0 |
England
Nigeria