| 31. Round | 05/02/2011 | AFC Bournemouth | - | Leyton Orient | 1:1 | ||||
| 32. Round | 12/02/2011 | Leyton Orient | - | Bristol Rovers | 4:1 | ||||
| 29. Round | 15/02/2011 | Milton Keynes Dons | - | Leyton Orient | 2:3 | ||||
| 34. Round | 26/02/2011 | Huddersfield Town | - | Leyton Orient | 2:2 | ||||
| 35. Round | 05/03/2011 | Leyton Orient | - | Notts County | 2:0 | ||||
| 36. Round | 08/03/2011 | Walsall FC | - | Leyton Orient | 0:2 | ||||
| 37. Round | 12/03/2011 | Leyton Orient | - | Oldham Athletic | 1:0 | ||||
| 38. Round | 19/03/2011 | Brentford FC | - | Leyton Orient | 2:1 | ||||
| 39. Round | 26/03/2011 | Leyton Orient | - | Yeovil Town | 1:5 | ||||
| 40. Round | 02/04/2011 | Charlton Athletic | - | Leyton Orient | 3:1 | ||||
| 45. Round | 30/04/2011 | Leyton Orient | - | Tranmere Rovers | 0:3 | ||||
| 46. Round | 07/05/2011 | Plymouth Argyle | - | Leyton Orient | 1:4 |
England
