| 15. Round | 22/01/2022 | Manchester United [U18] | - | Everton FC [U18] | 4:2 | ||||
| 19. Round | 05/03/2022 | Manchester United [U18] | - | Manchester City [U18] | 1:5 | ||||
| 21. Round | 19/03/2022 | Manchester United [U18] | - | Leeds United [U18] | 4:1 | ||||
| 13. Round | 29/03/2022 | Blackburn Rovers [U18] | - | Manchester United [U18] | 4:1 | ||||
| 24. Round | 23/04/2022 | Manchester United [U18] | - | Newcastle United [U18] | 6:0 | ||||
| 16. Round | 27/04/2022 | Wolverhampton Wanderers [U18] | - | Manchester United [U18] | 2:2 | ||||
| 25. Round | 30/04/2022 | Manchester United [U18] | - | Derby County [U18] | 3:0 | ||||
| 9. Round | 14/05/2022 | Manchester United [U18] | - | Nottingham Forest [U18] | 1:1 |
England