| 21. Round | 20/01/2023 | FC Den Bosch | - | Jong PSV | 1:0 | ||||
| 22. Round | 27/01/2023 | FC Den Bosch | - | MVV | 3:3 |  |
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| 23. Round | 03/02/2023 | TOP Oss | - | FC Den Bosch | 3:0 |  |
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| 24. Round | 10/02/2023 | FC Den Bosch | - | Jong Ajax | 4:2 | |
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| 25. Round | 17/02/2023 | AZ Alkmaar (J) | - | FC Den Bosch | 3:1 | ||||
| 26. Round | 26/02/2023 | FC Den Bosch | - | ADO Den Haag | 0:0 | ||||
| 27. Round | 03/03/2023 | PEC Zwolle | - | FC Den Bosch | 13:0 | ||||
| 29. Round | 17/03/2023 | FC Den Bosch | - | FC Dordrecht | 3:1 | ||||
| 30. Round | 26/03/2023 | Heracles Almelo | - | FC Den Bosch | 3:2 | ||||
| 31. Round | 02/04/2023 | FC Den Bosch | - | Willem II | 0:2 | ||||
| 32. Round | 07/04/2023 | NAC Breda | - | FC Den Bosch | 2:0 | ||||
| 33. Round | 14/04/2023 | FC Den Bosch | - | Helmond Sport | 1:2 | ||||
| 34. Round | 21/04/2023 | Roda JC Kerkrade | - | FC Den Bosch | 0:1 | ||||
| 35. Round | 28/04/2023 | FC Den Bosch | - | Telstar | 0:1 | ||||
| 36. Round | 08/05/2023 | FC Utrecht (J) | - | FC Den Bosch | 0:0 | ||||
| 37. Round | 12/05/2023 | FC Den Bosch | - | Almere City FC | 2:2 | ||||
| 38. Round | 19/05/2023 | De Graafschap | - | FC Den Bosch | 3:0 |
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