| 2. Round | 20/08/2021 | Middlesbrough FC U23 | - | Aston Villa U23 | 1:2 | ||||
| 4. Round | 10/09/2021 | Norwich City U23 | - | Aston Villa U23 | 4:2 | ||||
| 5. Round | 17/09/2021 | Aston Villa U23 | - | West Bromwich Albion U23 | 4:2 | ||||
| 10. Round | 31/10/2021 | Southampton FC U23 | - | Aston Villa U23 | 4:0 | ||||
| 11. Round | 08/11/2021 | Reading FC U23 | - | Aston Villa U23 | 2:2 | ||||
| 18. Round | 24/01/2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 13. Round | 31/01/2022 | Newcastle United U23 | - | Aston Villa U23 | 2:0 | ||||
| 20. Round | 21/02/2022 | Aston Villa U23 | - | Norwich City U23 | 2:0 | ||||
| 22. Round | 11/03/2022 | Aston Villa U23 | - | Southampton FC U23 | 2:2 | ||||
| 24. Round | 01/04/2022 | Aston Villa U23 | - | Stoke City U23 | 1:4 | ||||
| 15. Round | 18/04/2022 | Sunderland AFC U23 | - | Aston Villa U23 | 1:3 | ||||
| 26. Round | 02/05/2022 | Aston Villa U23 | - | Newcastle United U23 | 1:2 |
England