| 1. Round | 13/08/2022 | Southampton FC [U18] | - | Aston Villa [U18] | 3:3 |  |
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| 2. Round | 20/08/2022 | West Ham United [U18] | - | Southampton FC [U18] | 4:1 | ||||
| 3. Round | 27/08/2022 | Southampton FC [U18] | - | Chelsea FC [U18] | 2:2 | ||||
| 4. Round | 17/09/2022 | Crystal Palace [U18] | - | Southampton FC [U18] | 3:2 | ||||
| 5. Round | 01/10/2022 | Southampton FC [U18] | - | Fulham FC [U18] | 3:5 | |
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| 8. Round | 19/11/2022 | Arsenal FC [U18] | - | Southampton FC [U18] | 1:2 | ||||
| 15. Round | 11/02/2023 | Aston Villa [U18] | - | Southampton FC [U18] | 2:4 | |
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| 16. Round | 18/02/2023 | Southampton FC [U18] | - | Tottenham Hotspur [U18] | 0:1 | ||||
| 17. Round | 25/02/2023 | West Bromwich Albion [U18] | - | Southampton FC [U18] | 0:1 | ||||
| 12. Round | 04/03/2023 | Fulham FC [U18] | - | Southampton FC [U18] | 5:2 | |
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| 13. Round | 11/03/2023 | Southampton FC [U18] | - | Leicester City [U18] | 0:2 | ||||
| 19. Round | 01/04/2023 | Southampton FC [U18] | - | Crystal Palace [U18] | 1:7 | |
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| 22. Round | 29/04/2023 | Norwich City [U18] | - | Southampton FC [U18] | 4:1 |
England