| 2. Round | 28/08/2021 | Maidenhead United | - | Dover Athletic | 2:0 | ||||
| 3. Round | 30/08/2021 | Dover Athletic | - | Boreham Wood | 0:1 | ||||
| 4. Round | 04/09/2021 | Altrincham FC | - | Dover Athletic | 3:2 | ||||
| 5. Round | 11/09/2021 | Dover Athletic | - | Chesterfield FC | 0:0 | ||||
| 7. Round | 18/09/2021 | Weymouth FC | - | Dover Athletic | 1:1 | ||||
| 11. Round | 09/10/2021 | Dover Athletic | - | Barnet FC | 1:2 | ||||
| 14. Round | 30/10/2021 | Dover Athletic | - | Stockport County | 2:5 | ||||
| 13. Round | 02/11/2021 | Southend United | - | Dover Athletic | 4:1 | ||||
| 15. Round | 13/11/2021 | Torquay United | - | Dover Athletic | 2:1 |  |
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| 16. Round | 20/11/2021 | Dover Athletic | - | Halifax Town | 1:3 | ||||
| 17. Round | 23/11/2021 | Dover Athletic | - | Wealdstone FC | 2:3 |
Jamaica