| 11. Round | 07/11/2022 | Sunderland AFC U21 | - | Southampton FC U21 | 1:3 |  |
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| 14. Round | 27/01/2023 | Middlesbrough FC U21 | - | Southampton FC U21 | 2:2 | ||||
| 15. Round | 10/02/2023 | Southampton FC U21 | - | Sunderland AFC U21 | 2:2 | ||||
| 16. Round | 20/02/2023 | West Bromwich Albion U21 | - | Southampton FC U21 | 1:2 | ||||
| 17. Round | 24/02/2023 | Southampton FC U21 | - | Leeds United U21 | 1:2 | ||||
| 19. Round | 17/03/2023 | Aston Villa U21 | - | Southampton FC U21 | 1:2 | ||||
| 5. Round | 31/03/2023 | Derby County U21 | - | Southampton FC U21 | 1:3 |
England