| 1. Round | 14/08/2021 | Manchester City [U18] | - | Manchester United [U18] | 3:0 | ||||
| 2. Round | 21/08/2021 | Manchester United [U18] | - | Liverpool FC [U18] | 0:5 | ||||
| 3. Round | 28/08/2021 | Leeds United [U18] | - | Manchester United [U18] | 0:3 | ||||
| 6. Round | 02/10/2021 | Newcastle United [U18] | - | Manchester United [U18] | 0:5 | ||||
| 8. Round | 30/10/2021 | Derby County [U18] | - | Manchester United [U18] | 2:2 | ||||
| 26. Round | 06/11/2021 | Nottingham Forest [U18] | - | Manchester United [U18] | 0:2 | ||||
| 10. Round | 20/11/2021 | Burnley FC [U18] | - | Manchester United [U18] | 2:2 | ||||
| 11. Round | 04/12/2021 | Everton FC [U18] | - | Manchester United [U18] | 3:0 | ||||
| 21. Round | 19/03/2022 | Manchester United [U18] | - | Leeds United [U18] | 4:1 | ||||
| 22. Round | 02/04/2022 | Middlesbrough FC [U18] | - | Manchester United [U18] | 1:1 | ||||
| 12. Round | 05/04/2022 | Manchester United [U18] | - | Sunderland AFC [U18] | 1:1 | ||||
| 24. Round | 23/04/2022 | Manchester United [U18] | - | Newcastle United [U18] | 6:0 |
England