| 5. Round | 18/10/2020 | Southampton FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 6. Round | 23/10/2020 | Derby County U23 | - | Southampton FC U23 | 3:1 | ||||
| 8. Round | 07/11/2020 | Southampton FC U23 | - | Manchester City U23 | 5:2 | ||||
| 9. Round | 21/11/2020 | Liverpool FC U23 | - | Southampton FC U23 | 0:0 | ||||
| 7. Round | 04/12/2020 | Manchester United U23 | - | Southampton FC U23 | 3:1 | ||||
| 11. Round | 12/12/2020 | Southampton FC U23 | - | Leicester City U23 | 5:2 |  |
England