| 14. Round | 30/11/2021 | Leeds United | - | Crystal Palace | 1:0 | ||||
| 16. Round | 12/12/2021 | Crystal Palace | - | Everton FC | 3:1 | ||||
| 17. Round | 15/12/2021 | Crystal Palace | - | Southampton FC | 2:2 | ||||
| 19. Round | 26/12/2021 | Tottenham Hotspur | - | Crystal Palace | 3:0 | ||||
| 20. Round | 28/12/2021 | Crystal Palace | - | Norwich City | 3:0 | ||||
| 21. Round | 01/01/2022 | Crystal Palace | - | West Ham United | 2:3 | ||||
| 22. Round | 14/01/2022 | Brighton & Hove Albion | - | Crystal Palace | 1:1 |  |
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| 23. Round | 23/01/2022 | Crystal Palace | - | Liverpool FC | 1:3 | |
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| 24. Round | 09/02/2022 | Norwich City | - | Crystal Palace | 1:1 | ||||
| 25. Round | 12/02/2022 | Brentford FC | - | Crystal Palace | 0:0 | ||||
| 18. Round | 23/02/2022 | Watford FC | - | Crystal Palace | 1:4 | ||||
| 28. Round | 05/03/2022 | Wolverhampton Wanderers | - | Crystal Palace | 0:2 | |
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| 35. Round | 30/04/2022 | Southampton FC | - | Crystal Palace | 1:2 | ||||
| 36. Round | 07/05/2022 | Crystal Palace | - | Watford FC | 1:0 | |
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| 33. Round | 19/05/2022 | Everton FC | - | Crystal Palace | 3:2 | |
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| 38. Round | 22/05/2022 | Crystal Palace | - | Manchester United | 1:0 | |
England
