| 7. Round | 04/10/2021 | West Bromwich Albion U23 | - | Sunderland AFC U23 | 1:0 | ||||
| 9. Round | 22/10/2021 | Aston Villa U23 | - | Sunderland AFC U23 | 2:3 | ||||
| 12. Round | 21/11/2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | ||||
| 14. Round | 06/12/2021 | Newcastle United U23 | - | Sunderland AFC U23 | 2:0 |  |
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| 16. Round | 10/01/2022 | Sunderland AFC U23 | - | Reading FC U23 | 2:0 | ||||
| 17. Round | 16/01/2022 | Middlesbrough FC U23 | - | Sunderland AFC U23 | 3:2 | ||||
| 18. Round | 24/01/2022 | Sunderland AFC U23 | - | Wolverhampton Wanderers U23 | 1:2 | ||||
| 13. Round | 31/01/2022 | Sunderland AFC U23 | - | Nottingham Forest U23 | 1:1 | ||||
| 19. Round | 04/02/2022 | Fulham FC U23 | - | Sunderland AFC U23 | 2:0 | ||||
| 20. Round | 21/02/2022 | Sunderland AFC U23 | - | West Bromwich Albion U23 | 0:1 | ||||
| 21. Round | 28/02/2022 | Sunderland AFC U23 | - | Stoke City U23 | 0:3 | ||||
| 22. Round | 14/03/2022 | Nottingham Forest U23 | - | Sunderland AFC U23 | 3:0 | ||||
| 24. Round | 01/04/2022 | Norwich City U23 | - | Sunderland AFC U23 | 1:1 | ||||
| 15. Round | 18/04/2022 | Sunderland AFC U23 | - | Aston Villa U23 | 1:3 | ||||
| 26. Round | 01/05/2022 | Southampton FC U23 | - | Sunderland AFC U23 | 1:0 |
England