| 1. Round | 16/08/2021 | West Ham United U23 | - | Arsenal FC U23 | 6:1 | ||||
| 2. Round | 20/08/2021 | Arsenal FC U23 | - | Crystal Palace U23 | 4:2 |  |
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| 3. Round | 27/08/2021 | Tottenham Hotspur U23 | - | Arsenal FC U23 | 1:2 | ||||
| 8. Round | 16/10/2021 | Liverpool FC U23 | - | Arsenal FC U23 | 3:0 | |
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| 9. Round | 22/10/2021 | Arsenal FC U23 | - | Everton FC U23 | 4:0 | |
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| 10. Round | 29/10/2021 | Leeds United U23 | - | Arsenal FC U23 | 2:4 | ||||
| 11. Round | 06/11/2021 | Arsenal FC U23 | - | Leicester City U23 | 3:3 | ||||
| 14. Round | 06/12/2021 | Everton FC U23 | - | Arsenal FC U23 | 2:0 | ||||
| 18. Round | 21/01/2022 | Derby County U23 | - | Arsenal FC U23 | 1:1 | ||||
| 19. Round | 04/02/2022 | Arsenal FC U23 | - | Chelsea FC U23 | 3:1 | ||||
| 20. Round | 21/02/2022 | Leicester City U23 | - | Arsenal FC U23 | 1:1 | ||||
| 21. Round | 25/02/2022 | Arsenal FC U23 | - | Liverpool FC U23 | 1:4 |
England
USA