1st(1st leg) Lanús - Universidad de Chile 4:0 (3:0)
2nd (2nd leg) Universidad de Chile - Lanús 1:0 (0:0)
1st(1st leg): 19/09/2013 00:15 2nd (2nd leg): 25/09/2013 23:30 Winner: Lanús
1st(1st leg) La Equidad - Vélez Sarsfield 1:2 (0:0)
2nd (2nd leg) Vélez Sarsfield - La Equidad 2:1 (0:1)
1st(1st leg): 19/09/2013 02:30 2nd (2nd leg): 03/10/2013 01:15 Winner: Vélez Sarsfield
1st(1st leg) Liga de Loja - River Plate 2:1 (1:0)
2nd (2nd leg) River Plate - Liga de Loja 2:0 (1:0)
1st(1st leg): 20/09/2013 01:15 2nd (2nd leg): 26/09/2013 23:30 Winner: River Plate
1st(1st leg) Coritiba - PR - Itagüi Ditaires 0:1 (0:0)
2nd (2nd leg) Itagüi Ditaires - Coritiba - PR 2:1 (0:1)
1st(1st leg): 25/09/2013 01:00 2nd (2nd leg): 25/10/2013 02:00 Winner: Itagüi Ditaires
1st(1st leg) Ponte Preta - Deportivo Pasto 2:0 (1:0)
2nd (2nd leg) Deportivo Pasto - Ponte Preta 1:0 (0:0)
1st(1st leg): 25/09/2013 23:30 2nd (2nd leg): 23/10/2013 01:15 Winner: Ponte Preta
1st(1st leg) Libertad - Sport - PE 2:0 (2:0)
2nd (2nd leg) Sport - PE - Libertad 1:2 (0:1)
1st(1st leg): 26/09/2013 01:50 2nd (2nd leg): 24/10/2013 01:10 Winner: Libertad
1st(1st leg) São Paulo FC - Universidad Católica 1:1 (1:1)
2nd (2nd leg) Universidad Católica - São Paulo FC 3:4 (2:2)
1st(1st leg): 27/09/2013 02:00 2nd (2nd leg): 24/10/2013 00:50 Winner: São Paulo FC
1st(1st leg) Atlético Nacional - Bahia - BA 1:0 (1:0)
2nd (2nd leg) Bahia - BA - Atlético Nacional 3:4 (1:0, 1:0, 1:0) pso
1st(1st leg): 27/09/2013 02:00 2nd (2nd leg): 24/10/2013 23:30 Winner: Atlético Nacional