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| 22/01/2021 | 19:45 | Chorley FC | - | Wolverhampton Wanderers | 0:1 (0:1) | |
| 23/01/2021 | 12:15 | Southampton FC | - | Arsenal FC | 1:0 (1:0) | |
| 15:00 | Swansea City | - | Nottingham Forest | 5:1 (2:0) | ||
| 15:00 | Barnsley FC | - | Norwich City | 1:0 (0:0) | ||
| 15:00 | Millwall FC | - | Bristol City | 0:3 (0:1) | ||
| 15:00 | Brighton & Hove Albion | - | Blackpool FC | 2:1 (1:1) | ||
| 15:00 | Sheffield United | - | Plymouth Argyle | 2:1 (1:0) | ||
| 15:00 | West Ham United | - | Doncaster Rovers | 4:0 (2:0) | ||
| 17:30 | Cheltenham Town | - | Manchester City | 1:3 (0:0) | ||
| 24/01/2021 | 12:00 | Chelsea FC | - | Luton Town | 3:1 (2:1) | |
| 14:30 | Fulham FC | - | Burnley FC | 0:3 (0:1) | ||
| 14:30 | Brentford FC | - | Leicester City | 1:3 (1:0) | ||
| 17:00 | Manchester United | - | Liverpool FC | 3:2 (1:1) | ||
| 20:00 | Everton FC | - | Sheffield Wednesday | 3:0 (1:0) | ||
| 25/01/2021 | 19:45 | Wycombe Wanderers | - | Tottenham Hotspur | 1:4 (1:1) | |
| 26/01/2021 | 19:00 | AFC Bournemouth | - | Crawley Town | 2:1 (1:0) |
