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| 09/02/2021 | 17:30 | Burnley FC | - | AFC Bournemouth | 0:2 (0:1) | |
| 19:30 | Manchester United | - | West Ham United | 1:0 (0:0, 0:0) aet | ||
| 10/02/2021 | 17:30 | Swansea City | - | Manchester City | 1:3 (0:1) | |
| 19:30 | Sheffield United | - | Bristol City | 1:0 (0:0) | ||
| 19:30 | Leicester City | - | Brighton & Hove Albion | 1:0 (0:0) | ||
| 20:15 | Everton FC | - | Tottenham Hotspur | 5:4 (3:2, 4:4) aet | ||
| 11/02/2021 | 17:30 | Wolverhampton Wanderers | - | Southampton FC | 0:2 (0:0) | |
| 20:00 | Barnsley FC | - | Chelsea FC | 0:1 (0:0) |
