League Two   M. W D L goals
  at home 2 2 0 0 3 : 0
  Away 2 0 1 1 1 : 2
  4 2 1 1 4 : 2
EFL Trophy   M. W D L goals
  at home 1 1 0 0 3 : 0
  Away 1 0 0 1 0 : 2
  2 1 0 1 3 : 2
overall   M. W D L goals
  at home 3 3 0 0 6 : 0
  Away 3 0 1 2 1 : 4
  Neutral Place 0 0 0 0 0 : 0
  6 3 1 2 7 : 4
League Two
2022/2023 30. Round Leyton Orient - AFC Wimbledon 1:0 (0:0)
2022/2023 8. Round AFC Wimbledon - Leyton Orient 2:0 (2:0)
2015/2016 44. Round AFC Wimbledon - Leyton Orient 1:0 (1:0)
2015/2016 20. Round Leyton Orient - AFC Wimbledon 1:1 (1:0)
EFL Trophy
2020/2021 Group G South Leyton Orient - AFC Wimbledon 2:0 (1:0)
2019/2020 Group C AFC Wimbledon - Leyton Orient 3:0 (1:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking