League Cup   M. W D L goals
  Away 1 0 0 1 0 : 1
  1 0 0 1 0 : 1
League One   M. W D L goals
  at home 9 3 0 6 9 : 16
  Away 9 0 4 5 5 : 19
  18 3 4 11 14 : 35
League Two   M. W D L goals
  at home 3 2 0 1 6 : 3
  Away 3 2 0 1 2 : 1
  6 4 0 2 8 : 4
EFL Trophy   M. W D L goals
  at home 1 1 0 0 2 : 1
  1 1 0 0 2 : 1
overall   M. W D L goals
  at home 13 6 0 7 17 : 20
  Away 13 2 4 7 7 : 21
  Neutral Place 0 0 0 0 0 : 0
  26 8 4 14 24 : 41
League Cup
2006/2007 1. Round Milton Keynes Dons - Colchester United 1:0 (0:0, 0:0) aet
League One
2014/2015 24. Round Colchester United - Milton Keynes Dons 0:1 (0:1)
2014/2015 19. Round Milton Keynes Dons - Colchester United 6:0 (3:0)
2013/2014 24. Round Milton Keynes Dons - Colchester United 0:0 (0:0)
2013/2014 18. Round Colchester United - Milton Keynes Dons 3:1 (2:0)
2012/2013 40. Round Colchester United - Milton Keynes Dons 0:2 (0:1)
2012/2013 20. Round Milton Keynes Dons - Colchester United 5:1 (2:0)
2011/2012 24. Round Milton Keynes Dons - Colchester United 1:0 (0:0)
2011/2012 18. Round Colchester United - Milton Keynes Dons 1:5 (1:2)
2010/2011 37. Round Colchester United - Milton Keynes Dons 1:3 (1:0)
2010/2011 10. Round Milton Keynes Dons - Colchester United 1:1 (0:1)
2009/2010 25. Round Colchester United - Milton Keynes Dons 2:0 (1:0)
2009/2010 4. Round Milton Keynes Dons - Colchester United 2:1 (1:0)
2008/2009 25. Round Milton Keynes Dons - Colchester United 1:1 (0:1)
2008/2009 7. Round Colchester United - Milton Keynes Dons 0:3 (0:1)
2005/2006 22. Round Colchester United - Milton Keynes Dons 2:0 (1:0)
2005/2006 4. Round Milton Keynes Dons - Colchester United 1:1 (1:0)
2004/2005 28. Round Milton Keynes Dons - Colchester United 2:0 (2:0)
2004/2005 9. Round Colchester United - Milton Keynes Dons 0:1 (0:1)
League Two
2024/2025 34. Round Milton Keynes Dons - Colchester United 0:1 (0:0)
2024/2025 2. Round Colchester United - Milton Keynes Dons 2:0 (0:0)
2023/2024 24. Round Milton Keynes Dons - Colchester United 1:0 (0:0)
2023/2024 4. Round Colchester United - Milton Keynes Dons 2:3 (2:1)
2018/2019 45. Round Colchester United - Milton Keynes Dons 2:0 (1:0)
2018/2019 23. Round Milton Keynes Dons - Colchester United 0:1 (0:1)
EFL Trophy
2024/2025 Group E South Colchester United - Milton Keynes Dons 2:1 (1:1)

For games that were decided on penalties the score after 120 minutes will be included in the ranking