Championship   M. W D L goals
  at home 6 2 2 2 7 : 7
  Away 6 0 5 1 5 : 6
  12 2 7 3 12 : 13
League One   M. W D L goals
  at home 1 0 0 1 1 : 2
  Away 1 1 0 0 3 : 2
  2 1 0 1 4 : 4
League Two   M. W D L goals
  at home 6 1 2 3 7 : 10
  Away 6 1 2 3 4 : 8
  12 2 4 6 11 : 18
EFL Trophy   M. W D L goals
  at home 1 1 0 0 5 : 0
  1 1 0 0 5 : 0
overall   M. W D L goals
  at home 14 4 4 6 20 : 19
  Away 13 2 7 4 12 : 16
  Neutral Place 0 0 0 0 0 : 0
  27 6 11 10 32 : 35
Championship
1975/1976 9. Round Leyton Orient - Oxford United 2:1
1975/1976 3. Round Oxford United - Leyton Orient 2:1
1974/1975 8. Round Leyton Orient - Oxford United 1:1
1974/1975 2. Round Oxford United - Leyton Orient 1:2
1973/1974 8. Round Leyton Orient - Oxford United 1:1
1973/1974 3. Round Oxford United - Leyton Orient 1:1
1972/1973 7. Round Oxford United - Leyton Orient 2:1
1972/1973 1. Round Leyton Orient - Oxford United 1:1
1971/1972 3. Round Leyton Orient - Oxford United 1:1
1971/1972 1. Round Oxford United - Leyton Orient 1:1
1970/1971 9. Round Leyton Orient - Oxford United 0:0
1970/1971 8. Round Oxford United - Leyton Orient 0:1
League One
2023/2024 35. Round Oxford United - Leyton Orient 1:2 (1:0)
2023/2024 17. Round Leyton Orient - Oxford United 2:3 (0:2)
League Two
2015/2016 36. Round Oxford United - Leyton Orient 0:1 (0:0)
2015/2016 13. Round Leyton Orient - Oxford United 2:2 (0:2)
2005/2006 46. Round Oxford United - Leyton Orient 2:3 (1:1)
2005/2006 16. Round Leyton Orient - Oxford United 1:0 (1:0)
2004/2005 40. Round Oxford United - Leyton Orient 2:2
2004/2005 4. Round Leyton Orient - Oxford United 0:0
2003/2004 30. Round Leyton Orient - Oxford United 1:0
2003/2004 23. Round Oxford United - Leyton Orient 2:1
2002/2003 35. Round Oxford United - Leyton Orient 0:2
2002/2003 9. Round Leyton Orient - Oxford United 1:2
2001/2002 44. Round Oxford United - Leyton Orient 1:1
2001/2002 19. Round Leyton Orient - Oxford United 3:0
EFL Trophy
2022/2023 Group G South Oxford United - Leyton Orient 5:0 (2:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking