National League   M. W D L goals
  at home 2 1 0 1 2 : 1
  Away 2 0 1 1 2 : 3
  4 1 1 2 4 : 4
National League North   M. W D L goals
  at home 3 3 0 0 6 : 1
  Away 3 2 0 1 5 : 4
  6 5 0 1 11 : 5
overall   M. W D L goals
  at home 5 4 0 1 8 : 2
  Away 5 2 1 2 7 : 7
  Neutral Place 0 0 0 0 0 : 0
  10 6 1 3 15 : 9
National League
2016/2017 9. Round Southport FC - Guiseley AFC 0:1 (0:0)
2016/2017 3. Round Guiseley AFC - Southport FC 2:1 (0:0)
2015/2016 8. Round Southport FC - Guiseley AFC 2:0 (1:0)
2015/2016 2. Round Guiseley AFC - Southport FC 1:1 (1:0)
National League North
2021/2022 24. Round Southport FC - Guiseley AFC 2:1
2021/2022 13. Round Guiseley AFC - Southport FC 0:2
2020/2021 13. Round Guiseley AFC - Southport FC 4:2
2019/2020 3. Round Southport FC - Guiseley AFC 3:0
2018/2019 8. Round Guiseley AFC - Southport FC 0:1
2018/2019 6. Round Southport FC - Guiseley AFC 1:0

For games that were decided on penalties the score after 120 minutes will be included in the ranking